Connective Tissue Growth Factor Expression in Human Bronchial Epithelial Cells
نویسندگان
چکیده
منابع مشابه
Connective tissue growth factor expression in human bronchial epithelial cells.
Connective tissue growth factor (CTGF) is a cysteine-rich protein that promotes extracellular matrix deposition. CTGF is selectively induced by transforming growth factor beta and des-Arg kallidin in lung fibroblasts and increases steady-state mRNA levels of alpha type I collagen, 5alpha-integrin and fibronectin in fibroblasts. Bronchial epithelial cells have been proposed to functionally inter...
متن کاملEndothelin-1 Induces Expression of Connective Tissue Growth Factor in Bronchial Epithelial Cells
Endothelin-1 (ET-1) is a potent vaso and bronchoconstrictor. We have previously shown that in the presence of ET-1 bronchial epithelial cells migrate more slowly. Connective tissue growth factor (CTGF) is a cysteine rich secreted protein and regulates fibrosis. In addition, we have previously shown that CTGF is expressed in airway epithelial cells under the conditions of stress starvation. The ...
متن کاملRegulation of connective tissue growth factor (CTGF) by hepatocyte growth factor in human tubular epithelial cells.
BACKGROUND Hepatocyte growth factor (HGF) is a pleiotropic protein with renoprotective functions, which have been attributed at least in part to its ability to counteract the profibrotic effects of transforming growth factor beta (TGF-beta). A major downstream mediator of TGF-beta is connective tissue growth factor (CTGF). However, the molecular mechanisms of CTGF regulation by HGF have not yet...
متن کاملCharacterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia.
Tubular epithelial cells secrete connective tissue growth factor (CTGF, CCN2), which contributes to tubulointerstitial fibrosis. However, the molecular regulation of CTGF in human primary tubular epithelial cells (hPTECs) is not well defined. Therefore, CTGF expression was characterized in hPTECs isolated from healthy parts of tumor nephrectomies, with special emphasis on the regulation by tran...
متن کاملExpression of transcription factors Slug in the lens epithelial cells undergoing epithelial-mesenchymal transition induced by connective tissue growth factor.
AIM To investigate the expression of transcription factors Slug in human lens epithelial cells (HLECs) undergoing epithelial-mesenchymal transition (EMT) induced by connective tissue growth factor (CTGF). METHODS HLECs were treated with CTGF of different concentrations (20, 50 and 100 ng/mL) or without CTGF (control) for 24h. The morphological changes of HLECs were analysed by microscopy. The...
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2006
ISSN: 1672-9145,1745-7270
DOI: 10.1111/j.1745-7270.2006.00130.x